Estrogen Receptor-Positive Breast Cancer

ER-positive breast cancer is the most prevalent type of breast cancer diagnosed today. Most of these cases are ER-positive, meaning the cell has estrogen receptors on its surface that bind to estrogen. Breast cancer is classified as estrogen receptor-positive (ER-positive) when cells test positive for estrogen receptors. That means that estrogen is promoting cancer growth. It is one of several important breast cancer characteristics that help decide the best therapy options.

Several medications can be effective in treating hormone receptor-positive breast cancer. They can either block or damage the hormone receptors in the cells. Alternatively, they may lower hormone levels in the body. The goal of each of these treatments is to prevent cancer cell proliferation.

What Is A Hormone Receptor?

Hormones are chemical messengers that circulate throughout the body. Hormone receptors are proteins found within and outside of breast cells. When a hormone connects to a receptor, it instructs the cells to grow and divide. In the case of breast cancer, these receptors allow abnormal cells to proliferate uncontrollably, forming a tumor.

What Are Estrogen And Progesterone Receptors?

Estrogen and progesterone are hormones that can enhance the growth of breast cancer. These hormones connect to progesterone and estrogen receptors. A pathologist will perform an immunohistochemistry staining assay (IHC) on the tissue sample after a breast biopsy. The test can identify estrogen and progesterone receptors.

The hormone receptor status tells us much about how cancer will behave. It is also an important aspect in identifying the optimal treatment. Hormone therapy usually works effectively for HR-positive breast cancer. These treatments either inhibit hormone synthesis or interfere with their impact on breast cancer cells. HR-negative breast tumors, on the other hand, do not react to hormone therapy; thus, other treatment options will be more beneficial.

Symptoms Of ER-Positive Breast Cancer

ER-positive breast cancer symptoms are similar to many other forms of breast cancer. A lump in the breast is the most prevalent symptom.

Other signs and symptoms may include,

• Skin irritation or dimpling

• Nipple discharge

• Breast discomforts or nipple color changes, such as redness or thickening of nipple or breast skin

• A change in the shape of the breast

How Is ER-Positive Breast Cancer Treated?

There are several therapy options for ER-positive breast cancer. All ER-positive breast cancer patients will be prescribed hormone therapy, generally known as endocrine therapy. Breast cancer frequently necessitates a combination of treatments. Hormone therapy aims to keep estrogen from triggering cancer cell development. This can be carried out in various ways, including:

1. Blocking estrogen receptors

• Selective estrogen receptor modulators (SERMs)

• Selective estrogen receptor degrader (SERD)

1. Lowering estrogen levels

• Aromatase inhibitors

1. Suppressing ovarian function

• Luteinizing hormone-releasing hormone (LHRH) agonists

Cytotam 20mg Tablet contains Tamoxifen citrate. It is used to treat and prevent breast cancer. It is also used to treat infertility in women caused by a failure to produce and release eggs properly. Cancer is a disease in which cells multiply uncontrolled and abnormally. Cytotam 20mg Tablet competes with estrogen for binding to the estrogen receptor, decreases the estrogen receptor-dependent growth in breast tissue, and slows down the growth of cancer cells.