For people with severe organ failure, organ transplantation offers hope, replacing the function of the damaged organ and allowing the person to live an almost normal life. Organ transplantation is a surgical procedure in which the patient's damaged organ is replaced with a healthy organ from a donor (deceased or living). As wonderful as this process is, it also presents great challenges. One of the main problems associated with organ transplantation is the fear of transplant rejection.
Our immune system basically recognizes anything that is foreign to our body. So when pathogens such as viruses or bacteria enter our body, it recognizes them as foreign invaders and produces proteins called antibodies that destroy them and keep us healthy. Transplant rejection occurs when the recipient's immune system recognizes the transplanted organ as foreign and attacks it.
Any substance that causes the body to mount an immune response against that substance is called an antigen. Antigens include viruses, chemicals, or other substances that come from outside the body. The body's cells and tissues also contain antigens that can trigger an immune response. The more similar antigens between the recipient and the donor, the less likely the organ will be rejected. Doctors consider many factors and perform some tests to determine the appropriate organ match for a patient. Genetic testing can help to make the best possible match between donor and recipient.
Acute or chronic rejection may occur after transplantation. Acute rejection usually occurs shortly after a few months after transplantation and is usually successfully treated. Chronic rejection occurs gradually in the years after surgery. The body's constant immune response against the new organ gradually damages the organ and may eventually stop functioning. The causes of chronic rejection are poorly understood and treatment is often unsuccessful.
Immunosuppressants are drugs given during and after a transplant to prevent the body from rejecting the new organ. They are powerful drugs that suppress the immune system. Almost everyone undergoing a transplant should take these medications as directed.
Pangraf 0.5mg capsule is an immunosuppressive medicinal product that contains the medicinal substance tacrolimus. This medicine works by reducing the activity of the immune system and preventing it from attacking the transplanted organ. Be sure to tell your doctor about all other medications you are taking before taking this medication. Grapefruit or grapefruit juice should be avoided while taking this medicine. Pangraf 0.5 mg capsule contains lactose, so tell your doctor if you are lactose intolerant before starting treatment with this product.